04feb 25Journal club februari 2025
Door prof. dr. J. Toelen en dr. A. Raaijmakers wordt maandelijks een lijst samengesteld van interessante artikels uit de pediatrische literatuur.
Omdat het lastig is om alle literatuur door te nemen wordt deze lijst beschikbaar gesteld om zo een makkelijk overzicht te krijgen van alle nieuwigheden.
Voor de lijst volg onderstaande link:
As always we would like to point out some studies among the many interesting ones.
A study in the Journal of Pediatrics examined the relationship between teething and infant sleep using objective sleep measurements. Over four weeks, infants (3–18 months) were monitored using crib camera footage. Parents recorded tooth eruption timing, symptoms, and management strategies. Sleep metrics—including total sleep time, night awakenings, and parental crib visits—were compared between teething and non-teething nights. The results showed no significant differences in sleep patterns between teething and non-teething nights. However, over half of parents reported sleep disturbances during teething, though these subjective concerns were not supported by objective data. These findings challenge the belief that teething disrupts sleep.
A study in JAMA Pediatrics investigated the potential association between montelukast use and neuropsychiatric adverse events in children and adolescents. Previous reports have suggested a link, however the mechanism remains unclear. Using nationwide Swedish registry data, this cohort study included 74,291 children (aged 6–17 years) who used montelukast or long-acting β-agonists. The primary outcome was any neuropsychiatric adverse event, including anxiety, depression, sleep disorders, suicidal actions, behavioral dysregulation, and psychotic-like symptoms. During a mean follow-up of 5.8 months, 310 events occurred in montelukast users and 566 in LABA users. No significant differences were found across individual neuropsychiatric outcomes. This very large study found no evidence linking montelukast to neuropsychiatric risks in children and adolescents. These findings may help guide physicians in their asthma and allergic rhinitis treatment decisions.
A multicenter, randomized, non-inferiority trial investigated whether antibiotic treatment for uncomplicated appendicitis in children (aged 5–16) was inferior to appendicectomy by comparing failure rates. Conducted across 11 hospitals in five countries, patients were randomly assigned to either antibiotics or surgery. Treatment failure was defined as appendix removal in the antibiotic group, a normal appendix on pathology in the appendicectomy group, or additional procedures requiring anesthesia. 936 children were enrolled and at 12-month follow-up, treatment failure occurred in 34% of antibiotic-treated patients versus 7% in the surgery group. No deaths or serious adverse events occurred. Based on failure rates and a 20% non-inferiority margin, antibiotic treatment was found to be inferior to appendicectomy.
We hope that you enjoy the list
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